Secretion-related uptake of horseradish peroxidase in neurohypophysial axons.

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Secretion-related uptake of horseradish peroxidase in neurohypophysial axons

During secretion of the neurohypophysial hormones, oxytocin and vasopressin, secretory granule membrane is added to the plasma membrane of the axon terminals. It is generally assumed that subsequent internalization of this additional membrane occurs by endocytosis. In order to study this process, we have traced the uptake of intravenously injected horseradish peroxidase by neurohypophysial axon...

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Horseradish peroxidase (HRP) was injected intracerebrally to immature rats, once a day for 3 days. The animals were killed 24 hr after the last injection and the cellular and intracellular localization of the enzymatic tracer in the cerebral cortex was investigated by ultrastructural cytochemistry at the light and electron microscopic level as well as biochemically. By light microscopy it could...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 1976

ISSN: 0021-9525,1540-8140

DOI: 10.1083/jcb.70.2.294